Freiburg University Hospital

PhD Project

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Posted On:
Closing On:
Dienstag, 30th April 2019
Sonntag, 27th Oktober 2019
Department: Department of Radiology, Medical Physics
Location: Freiburg

Job Description:

The Depts. of Radiation Oncology and Radiology, Medical Physics are looking for a PhD student in com¬puter science, physics, biomedical engineering or a related field for a research project funded by the Klaus-Tschira-Foundation on

Radioproteomics to Evaluate the Individual Radiation Resistance
in Patients with Primary Prostate Carcinoma

In Germany, about one quarter of all newly diagnosed tumors in men are found in the prostate, and annually about 58.000 men receive the diagnosis of a prostate carcinoma (PCa). Every year, 12.000 patients with a PCa die of the consequences of the disease. One therapy option for PCa is radiation therapy (RT), but the outcome of RT varies tremendously as the PCa can exhibit a large variation in radiation resistance.
In this PhD project, new image and data analysis methods will be developed to predict the outcome of a RT in PCa patients based on multi-modality clinical imaging data and biological and histological information. A post-processing pipeline using novel artificial intelligence methods (e.g., convolutional neural networks) will be established using existing patient data for training. Furthermore, concepts for the integration of heterogeneous input data (images, proteomics, etc.) will be developed and tested with the aim to quantify and predict radiation resistance in all areas of the tumor.
The highly interdisciplinary work will be conducted at the Dept. of Radiology – Medical Physics (Prof. M. Bock) in close cooperation with the Depts. of Radiation Oncology (Dr. C. Zamboglou), Urology (Dr. K. Reichel) and Pathology (Prof. O. Schilling). The work includes the design, programming and testing of a post-processing algorithm using high-level programming environments (e.g., MatLab from MathWorks), and interaction with all clinical partners of the research consortium.

The successful candidate should have an interest and initial experience/background in:

  • Computer programming (preferably in MatLab, and C++)
  • Image processing
  • Convolutional Neural Networksp

We offer:

  • An interdisciplinary dynamic research Environment
  • State-of-the-art computer Equipment
  • High-level support from MathWorks

The starting date is negotiable. Please submit your application and documents (preferably by email) to:

Dr. Constantinos Zamboglou
University Medical Center Freiburg
Dept. Radiation Oncology
Robert-Koch Straße 3
79106 Freiburg

Prof. Dr. Michael Bock
University Medical Center Freiburg
Dept. Radiology - Medical Physics
Killianstraße 5a
79106 Freiburg

Preferred Skills:

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