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Montag, 17th Juli 2017
Samstag, 13th Januar 2018
PhD student @ Maastricht University and King’s College London with an interest in vascular PET/MRI
Position: Early Stage Researcher (PhD-student) in Marie Skłodowska-Curie ITN project (FHML/School for Cardiovascular Diseases/CARIM-Department of Radiology and Nuclear Medicine)
Summary: You will perform the PhD project “Hybrid PET/MRI of key aspects of plaque vulnerability in different vascular beds” within Maastricht University with a secondment in King’s College London. The project is part of a large international consortium of renown institutes on Imaging and Vascular Biology.
Job description: The Early Stage Researcher (ESR) will be trained within the Marie Skłodowska-Curie Innovative Training Network (ITN) INTRICARE and will perform the research project nr. 10 "Hybrid PET/MRI of key aspects of plaque vulnerability in different vascular beds", primarily within CARIM at Maastricht University under the supervision of Dr. M.E. Kooi and Prof.dr. R.M. Botnar in order to realise the objectives of INTRICARE (International Network for Training on Risks of vascular intimal Calcification And roads to Regression of cardiovascular diseasE).
INTRICARE is an interdisciplinary international consortium involving 4 leading academic institutions and 9 SME's from 6 countries. The ESR will engage in network-wide training events, public engagement activities and international collaboration through secondments, at industrial or academic partner institutions within the EU.
Objectives of the PhD position: The ESR aims to develop and employ state of the art hybrid molecular non-invasive imaging ((PET)/MRI) together with comprehensive multiparameter data analysis for the in-vivo assessment of “vulnerable” plaque. This will be approached in different vascular beds (carotids, coronaries) to provide morphologic, functional and molecular information on the development and response to treatment of atherosclerosis. Depending on the background of the PhD student, the project will be focused on patient studies (for an MD) or on technical developments (for a physicist or biomedical engineer). This project will be closely linked to other projects within INTRICARE and will have links to Siemens, which will provide their acquisition and reconstruction software for imaging sequences and clinical translation.
Methodologies: The ESR focuses on MRI and hybrid PET/MRI of plaque vulnerability. Maastricht and London have an identical clinical integrated PET/MRI system, a fully digital preclinical PET and identical clinical MRI systems and complementary expertise in cardiac and vascular PET imaging including MR carotid and coronary artery imaging, thereby providing an excellent research and training platform for cardiovascular PET/MRI. Human and preclinical PET/MRI studies will focus on vulnerable plaque characterization, i.e. endothelial permeability (contrast enhancement on LGE), inflammation (uptake of 18F choline in PET), plaque deformation, and intraplaque haemorrhage (hyperintense signal on T1w TFE MRI or short T1 on T1 map). As the major challenge for coronary plaque imaging using PET/MRI is respiratory and cardiac motion we will use the MR navigator for respiratory motion correction. Cardiac motion will be corrected using ECG-gating.
Expected results: At the end of the project, we will have 1) demonstrated the feasibility of imaging plaque vulnerability in different vascular beds with hybrid PET/MRI, 2) obtained more knowledge on processes leading to plaque destabilisation and clinical events. The project will be finalised with several papers in international peer-reviewed journals and a PhD thesis.
Secondments: The ESR will visit King’s College London (UK) for 5 months. Furthermore, the ESR will spend one month at Topstart in the final year of the project to write a grant application for a follow-up project.
At the time of the appointment: Applicants must not have resided or carried out his/her main activity (work, studies, etc.) in the Netherlands for more than 12 months in the 3 years immediately before appointment under the project; Applicants shall also be in the first four years of their research careers at the time of appointment by the host organisation and have not been awarded a doctoral degree. For more information on Marie Skłodowska-Curie Innovative Training Networks (ITNs), please see: http://ec.europa.eu/mariecurieactions.
Terms of employment: The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website https://www.maastrichtuniversity.nl/support/um-employees
Additional information and application: For more information and application see www.intricare.eu or contact: Dr. M.E. (Eline) Kooi, firstname.lastname@example.org or prof. dr. R.M. (René) Botnar, email@example.com.